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Chicken Bubble Biscuit Bake Casserole

A comforting one-dish meal combining succulent chicken with a creamy sauce topped with fluffy biscuits, perfect for family gatherings or busy weeknights.
Prep Time 15 minutes
Cook Time 35 minutes
Total Time 50 minutes
Course Casserole, Main Course
Cuisine American
Servings 6 servings
Calories 400 kcal

Ingredients
  

Main ingredients

  • 2 cups cooked chicken (shredded or diced; rotisserie works great)
  • 1 can 10.5 oz cream of chicken soup (or cream of mushroom)
  • 1/2 cup sour cream (or plain Greek yogurt)
  • 1/2 cup milk
  • 1 cup frozen mixed vegetables (like peas, carrots, corn, beans)
  • 1 tsp garlic powder
  • 1/2 tsp onion powder
  • 1 can 16 oz refrigerated biscuit dough (cut into quarters)
  • 1 cup shredded cheddar cheese (or mozzarella)
  • 1 tbsp melted butter (optional, for brushing)

Instructions
 

Preparation

  • Preheat your oven to 350°F (175°C).
  • Lightly grease a 9x13-inch baking dish.
  • In a large mixing bowl, combine the cooked chicken, cream of chicken soup, sour cream, and milk. Stir until well mixed and smooth.
  • Add the frozen mixed vegetables along with garlic powder, onion powder, salt, and pepper. Fold in the veggies.
  • Gently fold in the quartered biscuit pieces.
  • Pour the mixture into your prepared baking dish and spread it out evenly.
  • Sprinkle the shredded cheddar cheese evenly over the top.

Baking

  • Cover the dish with aluminum foil and bake for 20 minutes.
  • After 20 minutes, remove the foil and continue baking for an additional 10–15 minutes, until the biscuits are puffy and golden.
  • If desired, brush the top with melted butter before serving.

Notes

Store leftovers in an airtight container in the refrigerator for up to 3-4 days. Reheat in the microwave or oven.
Keyword Biscuit Bake, Chicken Casserole, Comfort Food, Easy Dinner, One-Dish Meal